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antiplatelet aggregation antiplatelet Search

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Data on antiplatelet aggregation, anticoagulation and antioxidant

Canna edulis Ker rhizome has been used in Traditional Vietnamese Medicine to prevent and treat heart diseases without thorough scientific evidence. The data presented in this article characterize the antiplatelet aggregation, anticoagulant and antioxidant activity of C. edulis rhizome extracts and the bio-guided isolation of bioactive compounds from the active fraction.

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New Copper Compounds with Antiplatelet Aggregation Activity

Tests for antiplatelet aggregation activities of all of the four compounds were conducted. Results: X-ray diffraction studies show that (L1) and (L2) exist in the enol-imine tautomeric form with a strong intramolecular hydrogen bond. NMR studies show that both ligands are found as enol-imine tautomers in CDCl3 solution.

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Antiplatelet drugs - PubMed Central (PMC)

Jan 09, 2006  Jan 09, 2006  Antiplatelet drugs are intended to prevent and/or reverse platelet aggregation in arterial thrombosis, most prominently in myocardial infarction and ischaemic stroke. Platelets aggregate as haemostatic plugs at the site of vascular injury, whereby bleeding is limited or arrested in advance of plasma coagulation (Figure 1). This function of ...

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Antiplatelet Therapy - Hematology.org - American Society of

Dec 01, 2008  Dec 01, 2008  Based on fundamental hematology research that defined the mechanisms of platelet aggregation, an American hematologist developed the next clinically effective antiplatelet agent, a monoclonal antibody against the platelet membrane protein that initiates aggregation (the glycoprotein (GP) IIb/IIIa complex). This drug (abciximab) was

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Semi-mechanistic modelling and simulation of inhibition of

Antiplatelet agents are a class of pharmaceuticals that decrease platelet aggregation and thus inhibit thrombus formation. We examined the relationships between plasma concentrations of antiplatelet agents (triflusal, clopidogrel and cilostazol) and the platelet aggregation inhibitory effect after dosing.

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Anti-inflammatory, Antiplatelet Aggregation, and ...

Compounds 4 and 6 showed potent anti-inflammatory activity, compound 2 possessed potent antiplatelet aggregation and antiangiogenesis activities, and compound 6 demonstrated antiangiogenesis activity. This fungal species can cause a human hemorrhagic disorder known as onyalai. In this study, we identified the active components with antiplatelet ...

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Antiplatelet drugs - PubMed Central (PMC)

Jan 09, 2006  Antiplatelet drugs are intended to prevent and/or reverse platelet aggregation in arterial thrombosis, most prominently in myocardial infarction and ischaemic stroke. Platelets aggregate as haemostatic plugs at the site of vascular injury, whereby bleeding is limited or arrested in advance of plasma coagulation (Figure 1). This function of ...

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Screening for the antiplatelet aggregation quality markers ...

Sep 05, 2020  To verify the antiplatelet aggregation activity of cryptotanshinone, dihydrotanshinone I, tanshinone I, tanshinone IIA, and rosmarinic acid, the inhibitory effects of these five compounds on platelet aggregation were determined. Fig. 6 shows that cryptotanshinone and rosmarinic acid can inhibit platelet aggregation in a dose-dependent

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(PDF) Phenolic Bioactives as Antiplatelet Aggregation ...

Phenolic Bioactives as Antiplatelet Aggregation Factors: The Pivotal Ingredients in Maintaining Cardiovascular Health. Oxidative Medicine and Cellular Longevity. Wissam Zam. Download PDF. Download Full PDF Package. This paper. A short summary

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Antiplatelet Agents Concise Medical Knowledge

Antiplatelet agents are medications that inhibit platelet aggregation, a critical step in the formation of the initial platelet plug. Abnormal, or inappropriate, platelet aggregation is a key step in the pathophysiology of arterial ischemic events. The primary categories of antiplatelet agents include aspirin, ADP inhibitors, phosphodiesterase ...

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List of Antiplatelet agents - Generics Only - Drugs

Antiplatelet agents are medicines that reduce the ability of platelets to stick together (called platelet aggregation) and inhibit the formation of blood clots. Antiplatelet agents play a major role in the treatment and prevention of myocardial infarction (heart attacks), stent thrombosis, and ischemic stroke (strokes caused by a blood clot).

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Semi-mechanistic modelling and simulation of inhibition of ...

Antiplatelet agents are a class of pharmaceuticals that decrease platelet aggregation and thus inhibit thrombus formation. We examined the relationships between plasma concentrations of antiplatelet agents (triflusal, clopidogrel and cilostazol) and the platelet aggregation inhibitory effect after dosing.

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Simultaneous screening and analysis of antiplatelet ...

showed good antiplatelet aggregation effect (Chen et al. 2016). As a further extension of the previous study, a method combining platelet bio-specific extraction and HPLC analysis was developed to screen and identify the antiplatelet active compounds in the total alkaloids extract (TAE) of Rhizoma Corydalis in the present study.

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cardiovascular and hematologic drug 5.pdf - Antiplatelet ...

Clopidogrel (Plavix) Antiplatelet/ADP inhibitors: Inhibits adenosine diphosphate (ADP) a promoter of platelet receptor binding. It irreversibly inhibits ADP mediated platelet aggregation. It is a prodrug, it must be activated to inhibit platelet aggregation. Primary done in liver.

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In Vitro Antiplatelet Aggregation Activity of Centella ...

antiplatelet aggregation activity. Keywords: antiplatelet aggregation, Centella asiatica, n-hexane purification INTRODUCTION Platelet aggregation has many benefits for organism such as on homeostasis, xenobiotic phagocytoses, interaction with virus, bacteria or antigen-antibody complexes. However, it also has dangerous effects.

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Synthesis and Antiplatelet Aggregation Activities in Vitro ...

Sep 23, 2014  Synthesis and Antiplatelet Aggregation Activities in Vitro of N,N-di(3-Substitutedphenyl)-4-Methoxyl Benzene-1,3-Disulfonamides. Xiu Jie Liu 1 *, Chao Qing Wang 1, Xiao Wang 2, Qing Xiang Zhang 1, Kai Liu 1. The College of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, P.R. China

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Antiplatelet drugs Treatment summary BNF content ...

Antiplatelet drugs decrease platelet aggregation and inhibit thrombus formation in the arterial circulation, because in faster-flowing vessels, thrombi are composed mainly of platelets with little fibrin. Use of aspirin in primary prevention of cardiovascular disease, in patients with or without diabetes, or hypertension, is not recommended.

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IJMS Free Full-Text Multiparameter Evaluation of the ...

Current antiplatelet drugs for the treatment of arterial thrombosis often coincide with increased bleeding risk. Several tyrosine kinase inhibitors (TKIs) for cancer treatment inhibit platelet function, with minor reported bleeding symptoms. The aim of this study was to compare the antiplatelet properties of eight TKIs to explore their possible repurposing as antiplatelet drugs.

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New p-quinonoid aporphine alkaloids and antiplatelet ...

The structures of these compounds were elucidated by spectral analysis. Among the isolates obtained till now, five compounds, ovigerine (4), hernangerine (5), N-methylhernangerine (6), (+)-malekulatine (7), and isovanillin (8) showed moderate antiplatelet aggregation activity in vitro.

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Antiplatelet aggregation and antithrombotic benefits of ...

Jan 09, 2019  Antiplatelet aggregation and antithrombotic benefits of terpenes and flavones from hawthorn leaf extract isolated using the activity-guided method P. Gao, S. Li, K. Liu, C. Sun, S. Song and L. Li, Food Funct., 2019, 10, 859 DOI:

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Antiplatelet drugs - PubMed Central (PMC)

Jan 09, 2006  Antiplatelet drugs are intended to prevent and/or reverse platelet aggregation in arterial thrombosis, most prominently in myocardial infarction and ischaemic stroke. Platelets aggregate as haemostatic plugs at the site of vascular injury, whereby bleeding is limited or arrested in advance of plasma coagulation (Figure 1). This function of ...

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Antiplatelet Aggregation and Antithrombosis Efficiency of ...

2.4. Antiplatelet Aggregation Activity In Vitro. The antiplatelet activity of Pt-A and Pt-B was evaluated in ADP-induced platelet aggregation assays described by Born . The venous blood was from healthy volunteers free from aspirin or other nonsteroidal anti-inflammatory drugs for more than 7

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Synthesis and antiplatelet evaluation of alpha-methylene ...

In a search for inhibitors of platelet aggregation, some alpha-methylene-gamma-butyrolactones bearing 2-methylquinoline and 8-hydroxyquinoline moieties were synthesized and evaluated for antiplatelet activities against thrombin (Thr)-, arachidonic acid (AA)-, collagen (Col)-, and platelet-activating factor (PAF)-induced aggregation in washed rabbit platelets.

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Antiplatelet Therapy - Hematology.org

Dec 01, 2008  Based on fundamental hematology research that defined the mechanisms of platelet aggregation, an American hematologist developed the next clinically effective antiplatelet agent, a monoclonal antibody against the platelet membrane protein that initiates aggregation (the glycoprotein (GP) IIb/IIIa complex). This drug (abciximab) was approved by ...

Read More
In Vitro Antiplatelet Aggregation Activity of Centella ...

antiplatelet aggregation activity. Keywords: antiplatelet aggregation, Centella asiatica, n-hexane purification INTRODUCTION Platelet aggregation has many benefits for organism such as on homeostasis, xenobiotic phagocytoses, interaction with virus, bacteria or antigen-antibody complexes. However, it also has dangerous effects.

Read More
(PDF) Phenolic Bioactives as Antiplatelet Aggregation ...

Aug 17, 2021  It has been shown that phenolic compounds have antiplatelet aggregation abilities and a positive impact in the management of CVD, exerting

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Antiplatelet aggregation activity of diterpene alkaloids ...

Aug 02, 2002  3.3.. Comparison of in vitro antiplatelet activities of atisine-type alkaloids with those of ginkgolide B and aspirinA comparison of the inhibitory effects of atisine-type alkaloids, ginkgolide B and aspirin on PAF, arachidonic acid and ADP-induced platelet aggregation is shown in Table 1.Of the 14 test compounds, 12 selectively inhibited platelet aggregation induced by PAF.

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Synthesis and Antiplatelet Aggregation Activities in Vitro ...

Sep 23, 2014  Synthesis and Antiplatelet Aggregation Activities in Vitro of N,N-di(3-Substitutedphenyl)-4-Methoxyl Benzene-1,3-Disulfonamides. Xiu Jie Liu 1 *, Chao Qing Wang 1, Xiao Wang 2, Qing Xiang Zhang 1, Kai Liu 1. The College of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, P.R. China

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Antiplatelet drug Britannica

Antiplatelet drug, any drug that interferes with the aggregation of platelets and formation of a clot (thrombus) in a blood vessel.Clot formation in coronary arteries may cut off the blood supply to a region of the heart and cause a myocardial infarction (heart attack). When administered during a heart attack, antiplatelet drugs can reduce the extent of damage to the heart muscle and the ...

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Progress in the development of antiplatelet agents: Focus ...

Nov 01, 2019  Currently, the study of antiplatelet agents targeting P-selectin is rare; however, the previous study has suggested that its use is a new direction in the development of novel antiplatelet agents. 7. Anti-coagulant. Platelet aggregation and subsequenent blood coagulation cascades together result in thrombosis.

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Antiplatelet medications Osmosis

Antiplatelet medications inhibit the steps of primary hemostasis to prevent the platelet plug from forming. Primary hemostasis can be further divided into five steps: endothelial injury, exposure, adhesion, activation, and aggregation. Endothelial injury is when the innermost layer of the artery, called the endothelium, gets damaged.

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Frontiers Antiplatelet Agents Have a Distinct Efficacy ...

Antiplatelet agents significantly reduced aggregation induced by the two bacterial species. Among the antiplatelet agents taken orally and for long term, ticagrelor and the combination (aspirin–ticagrelor) showed the greatest decrease with S. aureus and S. sanguinis respectively (framed aggregates).

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Antiplatelet Drug - an overview ScienceDirect Topics

Various antiplatelet and anticoagulant agents are used in clinical practice. The oldest antiplatelet agent is aspirin. Circulating platelets in blood are essential for the formation of blood clots because after platelet aggregation, these aggregates are bound together by fibrin, thus forming blood clots.

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